Folic acid metabolism is at moderate risk during preparation for pregnancy and during pregnancy when folic acid is taken in doses of about 400-800 mcg per day. Folic acid has beneficial effects on both maternal and fetal development. Folic acid supplementation reduces the risk of fetal neural tube formation malformations, reduces the risk of fetal birth defects, prevents anemia in pregnant women to some extent, and reduces the risk of pre-eclampsia in pregnant women. For folic acid metabolism moderate risk of women although in the utilization of folic acid there are certain defects, but basically normal, in the preparation for pregnancy in the first trimester and early pregnancy folic acid supplementation with normal pregnant women can be, about 400-800 micrograms / day. Pregnant women taking folic acid during the period to avoid drinking tea, coffee, regular maternity review, maintain a comfortable mood, avoid exertion, pay attention to rest.