High platelet volume distribution width generally refers to high platelet distribution width, which needs to be considered in combination with other indicators, and may be related to hematologic diseases, such as megaloblastic anemia, giant platelet syndrome, etc. It is recommended to consult a specialist. 1. Platelet distribution width is one of the routine blood tests, which can reflect the dispersion of platelet volume size, and is often expressed as the coefficient of variation of individual platelet volume size, with a normal value of 15%-17%, which is helpful for the judgment of bone marrow hematopoietic function and diagnosis and treatment of certain hematological disorders. 2. Increased platelet distribution width suggests that the platelet size is disparate, which is mostly seen in certain hematologic diseases, such as acute chronic myeloid leukemia, megaloblastic anemia, splenectomy, thrombotic diseases, etc. 3. Platelet distribution width is usually checked by venous blood collection, without fasting, and with a light diet. Patients with anemia, splenectomy, thrombophilia, etc. are suitable for the test. It is recommended to find out the cause of high platelet distribution width in time and follow the doctor’s instructions to avoid delaying the condition.