In general, early surgical removal of small mesenchymal tumors of the fundus of the stomach is recommended after detection. However, the specifics vary from person to person. Fundic mesenchymal tumor is a kind of junctional tumor originating from the mesenchymal tissue of the stomach with a potential malignant tendency. In current clinical practice, this disease is more serious, so after the discovery of fundal mesenchymal tumor, the best treatment is to remove it by surgical means, in order to prevent cancerous transformation in the later stage, which will gradually develop distant metastasis, thus endangering the patient’s life. After the surgery, according to the individual situation of each patient, molecular targeting therapy should be supplemented to prevent the recurrence of mesenchymal tumor. After surgery, people should pay attention to forming regular dietary and living habits, and quit smoking and drinking, so as to facilitate the recovery of the condition. As to whether people with small mesothelioma in the fundus of the stomach need surgery or not, it is recommended to go to a regular hospital for examination and then have the next treatment plan formulated by a professional doctor. Regardless of whether surgical treatment is needed, the condition of gastric mesenchymal tumor should be regularly rechecked.