High aminotransferase may be caused by hepatitis B, fatty liver, cirrhosis, etc. Other causes include autoimmune hepatitis, drug liver injury, biliary tract disease, and late night exertion. 1. Hepatitis B: liver cells contain aminotransferases, and hepatitis B virus is a kind of hepatophilic virus, which can lead to liver damage, which can lead to necrosis of liver cells, and aminotransferases are released from the liver to the blood, which can lead to the elevation of aminotransferases. 2. Fatty liver: Fatty liver can cause fat droplets to be deposited in the liver cells, and when the deposition reaches a certain level, it can cause liver cell degeneration and necrosis. The necrosis of liver cells will release the internal transaminases into the blood, which will increase the transaminases in the blood. 3. Cirrhosis: Cirrhosis causes the normal structure of liver cells to be damaged, which can cause the necrosis of liver cells, and the transaminases hidden in the liver cells will enter into the blood, which can lead to high transaminases. There are many other reasons for high aminotransferase, such as autoimmune hepatitis, drug-related liver injury, biliary tract diseases, late-night fatigue can cause high aminotransferase, you need to go to the regular hospital in time for relevant examinations, to clarify the cause of the disease and then standardized treatment, to avoid causing delays in the condition.