Does P16 and Ki67 positivity necessarily mean cervical cancer?

P16 and Ki67 positivity does not confirm the diagnosis of cervical cancer, and further imaging and pathology biopsy are needed to confirm the diagnosis.
P16 and Ki67 are immunohistochemical tests, which are mainly used for the auxiliary diagnosis of cervical cancer and pre-cancerous lesions of the cervix, suggesting the possibility of cervical cancer, but not confirming the diagnosis of cervical cancer.
It is recommended that further tests such as imaging tests such as electron computed tomography, nuclear magnetic resonance and pathology biopsy should be performed to confirm the diagnosis. Among them, pathological biopsy is the gold standard to confirm the diagnosis of cervical cancer.
Therefore, when P16 and Ki67 are positive, it is recommended to undergo further tests under the guidance of a doctor and to receive active treatment after the disease is diagnosed.