The current anti-hepatitis B virus drugs are divided into two categories: interferons and nucleoside analogs. The interferons are common interferon and long-acting interferon, and the nucleoside analogues are lamivudine, adefovir, entecavir, tipifovir and tenofovir, of which tenofovir is not yet available in China. The specific medication should be combined with clinical, by the doctor face-to-face guidance shall prevail. 1, interferon: advantages: ① efficacy, e antigen conversion rate is high; ② there is no drug resistance phenomenon; ③ immunomodulatory effect; ④ course of treatment is relatively fixed. Disadvantages: ① inconvenient to administer by injection; ② more side effects; ③ not suitable for patients with cirrhosis; ④ inconvenient to carry. 2. Nucleoside analogues: Advantages: ① rapid inhibition of virus, strong effect; ② oral administration, one tablet a day, easy to carry; ③ few and mild adverse reactions; ④ suitable for patients with cirrhosis in the decompensated stage. Disadvantages: ①High resistance rate and cross-resistance; ②No immunomodulatory effect, no fixed course of treatment; ③High rebound rate after discontinuation of the drug. Regardless of whether interferon or nucleoside analogue antiviral therapy is used, it must be used carefully under the guidance of a physician, and the indications for antiviral therapy must be strictly mastered; inappropriate treatment will not only increase the economic burden, but also increase the difficulty of subsequent treatment.