You cannot check for H. pylori while taking omeprazole. The most commonly used method to detect H. pylori is the non-invasive method of urea breath test, which is often referred to as C13, C14. omeprazole belongs to the proton pump inhibitor, which can inhibit the secretion of gastric acid, increase the pH level in the stomach, thus inhibiting the activity of H. pylori urease, which affects the results, so it is necessary to discontinue the use of proton pump inhibitor for at least 2 weeks, so you can’t check for H. pylori while you’re taking omeprazole. In addition to proton pump inhibitors, antimicrobial drugs inhibit the growth of H. pylori and reduce its activity, significantly affecting the detection of H. pylori based on the urease activity test, resulting in false-negative results, so you need to stop using antimicrobial drugs for more than 4 weeks before you can check H. pylori. H. pylori testing requires attention to stopping proton pump agents for more than 2 weeks and antibacterial drugs for more than 4 weeks, and it is also not advisable to check for H. pylori during the administration of bismuth and traditional Chinese medicines, to avoid false negatives, which can affect the judgment of the condition. If there is a positive Helicobacter pylori, you should go to the hospital and be treated under the guidance of a professional doctor.