The appearance of hypertension at the age of 40 can be categorized into primary hypertension and secondary hypertension. Primary hypertension is mostly caused by heredity, high salt, smoking and obesity, while secondary hypertension is mostly caused by renal and endocrine diseases. 1. Lifestyle: high salt diet is the sensitive factor of hypertension pressure, followed by obesity, excessive alcohol consumption and heavy smoking. 2. Kidney diseases: Acute nephritis, chronic nephritis, diabetic nephropathy, chronic pyelonephritis and other substantial kidney diseases can lead to hypertension, which is the most common secondary hypertension, followed by renal vascular lesions such as renal artery stenosis can also lead to. 3. Endocrine diseases: such as primary aldosteronism, pheochromocytoma, cortisolism and so on, all of which can be manifested as hypertension. The presence of increased blood pressure, need to actively seek medical attention, clear cause for targeted treatment.