High anti-thyroid peroxidase antibodies may be associated with diseases such as Hashimoto’s thyroiditis, which may present with neck lumps, dyspnea, hyperthyroidism or hypothyroidism. Consultation with a doctor is recommended. 1. Neck lumps: Diffuse swelling of the thyroid gland, which can be palpated as lumps and nodules in the neck. 2. Difficulty in breathing: when the goiter presses on the trachea, there will be difficulty in breathing and sometimes hoarseness. 3. Early thyroiditis may have hyperthyroidism symptoms, irritability, accelerated basal metabolism, excessive food and hunger, sweating, tachycardia, etc. 4. In the late stage of Hashimoto’s thyroiditis, hypothyroidism, apathy, bradycardia, and mucous edema are present and require thyroxine supplementation. If anti-thyroid peroxidase antibody is elevated, you should go to the hospital in time, under the guidance of specialists, to carry out thyroid function and thyroid ultrasound and puncture diagnosis, to determine the nature of thyroid disease, targeted treatment.