Lung puncture biopsy may be painful but can be tolerated. Lung puncture biopsy is usually performed under ultrasound or CT guidance and is an invasive test. Local anesthesia is required before the puncture, which can alleviate the pain caused by the puncture, but can be tolerated by most people. This is because the puncture needle is punctured subcutaneously into the lungs to obtain a pathologic specimen, the needle is inserted instantly and withdrawn relatively quickly, and there is usually no significant pain. It is important to note that lung puncture biopsies typically bleed a small amount. However, if a local blood vessel is damaged during puncture, it may cause hemorrhage, and the chest needs to be opened to stop bleeding if necessary. Patients are advised to consult with their medical professionals in detail about the precautions and possible complications of puncture biopsy before undergoing lung puncture biopsy and make good preparations before the procedure.