The ascending colon, especially the hepatic flexure of the colon, is closely related to the descending and transverse part of the duodenum and the head of the pancreas, and colon cancer in this area is prone to duodenal or/and head of the pancreas involvement. The basic principles of tumor-free surgery include: (1) No contact principle: try not to touch and squeeze the tumor during surgery; (2) Isolation principle: for tumors invading the gastrointestinal plasma membrane (epithelium), wrap the tumor with medical glue or medical dressing during surgery to prevent tumor cells from shedding into the peritoneal cavity during surgery and increase the risk of peritoneal tumor metastasis (3) Principle of whole-block resection: for patients with adjacent organ involvement, the tumor should not be separated from the involved organ, but the whole block should be resected with the involved organ to avoid tumor cell dissemination and bleeding during surgery; (4) Principle of thermal chemotherapy for tumor inactivation: repeatedly soak and rinse the abdominopelvic cavity with large amount of hot distilled water to extinguish abdominal tumor shedding cells and prevent abdominal implantation and metastasis, and wash the intestinal canal near the anastomosis with sterile liquid. The intestinal canal near the anastomosis can reduce the chance of intestinal shedding tumor cells to colonize the anastomosis and reduce the chance of recurrence of anastomotic implantation after surgery. Male, 46 years old, colon cancer invaded the duodenum and head of the pancreas, right hemicolectomy combined with pancreaticoduodenectomy was performed to achieve radical surgery.