Leg pain in the early stages of leukemia is mainly seen in acute lymphoblastic leukemia, and can also occur in acute myeloid leukemia. In acute lymphoblastic leukemia, the infiltration of white blood cells in the patient’s body into the bones as well as joints and other parts of the body leads to symptoms such as leg pain and sternal pain, in addition to anemia, fever, infection, bleeding and other symptoms in the early stages of the disease. Common symptoms of leukemia are anemia, pain in bones and joints, infection, bleeding, fever, etc., accompanied by other symptoms such as fatigue, excessive sweating and weight loss. It is recommended that patients go to the hospital for professional examination in time to clarify the cause of the disease and then follow the doctor’s instructions for scientific and effective treatment.