Ceftriaxone sodium is more effective in treating syphilis, and early syphilis can be cured, and there are many successful cases of cure in the clinic. But the preferred treatment is still penicillin. Syphilis is a sexually transmitted disease caused by the syphilis spirochete, which is mainly transmitted through sexual contact, mother and child, and blood. The first choice of treatment is penicillin drugs such as benzylpenicillin, or ceftriaxone sodium for alternative treatment, and tetracycline drugs such as doxycycline can be used for those who are allergic to penicillin. Early syphilis without other systemic changes can be cured with appropriate and timely treatment. Late syphilis often involves internal organs, affecting the function of organs and thus affecting life and even life, the treatment can not reverse the organic damage that has been formed in the body, the prognosis is poor. It is recommended to take medication strictly under the guidance of a doctor to avoid deterioration of the condition, regular review to monitor the effect of treatment, and do a good job of personal hygiene care and isolation to prevent the spread of the disease.