This screenshot is a diagram on glycemia and cardiovascular disease from the ESC diabetes guidelines. From this diagram we can see: 1. Insulin resistance has been present in diabetes since the beginning, so the 2nd edition of internal medicine says that type 2 diabetes is diabetes that ranges from insulin resistance predominantly accompanied by insulin relative hypersecretion as a supplement to insulin hypersecretion predominantly accompanied by insulin resistance as a supplement. 2, Before diabetes is diagnosed, it has experienced several years to decades of abnormal blood glucose. 3, The diagnosis of diabetes mellitus is based on microvascular complications, that is, retinopathy as a cut-off point. The graph shows that macroangiopathy was already present before diabetes was diagnosed. So some young patients can develop acute cardiovascular accidents even if their fasting blood glucose is normal – the diagnostic criteria for diabetes are not only fasting blood glucose but also 2 hours postprandial blood glucose – this is the risk factor for acute cardiovascular accidents in young patients. 4. From this chart, we can see that in the early stage of diabetes diagnosis, fasting blood glucose may be normal, so according to that previous scale, when one is at high risk of diabetes, one should monitor blood glucose regularly, especially postprandial blood glucose. 5, The early stage of diabetes should be the decrease of insulin sensitivity, because this icon suggests that endogenous insulin secretion is more at the time of abnormal glucose tolerance.