Gallbladder perforation often manifests as limited or diffuse peritonitis, pericholecystic abscess and other manifestations. 1. Limited peritonitis: if the gallbladder perforation is wrapped by the greater omentum and surrounding tissues, it is mostly limited peritonitis, manifested by fever, limited abdominal pain, pressure and rebound pain at the point of gallbladder, and localized muscle tension. 2. Diffuse peritonitis: if the perforation of gallbladder is not confined, the bile will flow into the abdominal cavity leading to more serious diffuse peritonitis, manifested by fever, chills, diffuse abdominal pain, abdominal pressure, rebound pain and muscle tension, and even plate-like abdomen, shock and other manifestations. 3. Periportal gallbladder abscess: If there is adhesion of surrounding tissues around the gallbladder at the time of perforation, periportal abscess will be formed by wrapping around the peripheral tissues after the perforation, and the abdominal mass can be touched, accompanied by epigastric discomfort and other symptoms. Gallbladder perforation is a common complication of acute cholecystitis and other biliary tract diseases, people with gallbladder disease should be treated in time to prevent the occurrence of gallbladder perforation.