Pulmonary nodules do not present with chest pain, but if they do, the size and nature of the nodule needs to be determined as soon as possible. If the pulmonary nodule is a calcified nodule and the patient has had previous tuberculosis, the chest pain caused by this nodule is most often due to the pulling of the calcified nodule. If the lung nodule is larger than 8 mm or more, showing partial solid nodular changes with short burrs, pleural traction sign, lobar, pleural depression sign, the patient is a long-term smoker and has recently developed frequent cough, chest pain, and blood in sputum. At this time, early lung cancer, that is, peripheral type lung cancer, should be highly suspected, and enhanced CT of the chest should be given as soon as possible, and if necessary, percutaneous lung puncture should be given to obtain pathological tissue, or a thoracic surgeon can be asked to perform early surgical intervention to remove the lesion as soon as possible to see if it is a cancerous lesion. Therefore, once a lung nodule appears with chest pain, it needs to be paid high attention to avoid misdiagnosis and omission.