Hepatitis B surface antigen negativity and hepatitis B surface antibody positivity can be the result of self-healing from hepatitis B infection or from hepatitis B vaccination. After a healthy adult is infected with the hepatitis B virus, the vast majority of people are able to rely on their own immunity to clear the virus. The hepatitis B virus is cleared through autoimmunity, and the hepatitis B surface antigen turns negative. Hepatitis B surface antibody turns positive, and at the same time, there will be a combination of positive hepatitis B e antibody and hepatitis B core antibody, which is a self-healing condition after hepatitis B infection. Healthy adults who are not infected with hepatitis B virus can produce protective hepatitis B surface antibodies by stimulating the body’s immune system after hepatitis B vaccination. It is also normal to be negative for hepatitis B surface antigen and positive for hepatitis B surface antibody.