Proton pump inhibitors (PPIs for short) are a commonly used drug for treating acid reflux, and drugs like omeprazole, esomeprazole as well as lansoprazole belong to this category. Because they can inhibit the secretion of stomach acid, they are popular with some friends who suffer from stomach pain and acid reflux. Since many proton pump inhibitors are over-the-counter medications, they can be taken without a doctor’s supervision, so they have also become “health supplements” in the pockets of friends who often fight at the drinking table. A recent study showed that regular users of proton pump inhibitors had a 32% higher risk of reduced kidney function and a 28% higher risk of developing new chronic kidney disease than the general population. Further analysis also found that the frequency of kidney damage was directly proportional to the frequency of drug use, with patients who took the drug twice a day having a 46% increased risk of chronic kidney disease compared to those who took the drug once a day. The prevalence of chronic kidney damage was also 28% higher with proton pump inhibitors compared to traditional acid-suppressing H2 blockers (e.g., cimetidine, also known as metformin or Tylenol, ranitidine, and famotidine). Why are proton pump drugs prone to kidney damage? Omeprazole was first reported to cause acute interstitial nephritis in 1992, and other proton pump inhibitors have been reported to cause acute interstitial nephritis. The specific pathogenic mechanism is still unclear, and most scholars believe that proton pump inhibitors may act as a kind of semi-antigen that can induce autoimmune injury leading to kidney damage. At present, the renal injury of such drugs has attracted the attention of doctors specializing in nephrology and gastroenterology. Nonetheless, proton pump inhibition remains a very critical drug in the treatment of GI diseases. For some patients with clear therapeutic indications must still be used, but for some patients who can be used or not, it is recommended to consider carefully, for patients with kidney disease, in addition to taking proton pump inhibitors should be careful, as well as other drugs. It is worth pointing out that the elderly is a high incidence of renal damage, the elderly kidney excretory function of the physiological decline, that is, the routine use of pharmaceutical drugs are also prone to cause kidney damage. Although the elderly disease, take more drugs, but to do to distinguish between primary and secondary, light and heavy, can not use drugs try not to abuse drugs. A long and healthy life is not obtained through medication, but a healthy lifestyle.