What is the current overall status of treatment for pancreatic cancer? What is the survival rate of patients? What difficulties are still faced in its treatment? (Is the effect of chemotherapy satisfactory? The overall 5-year survival rate has been less than 5%. Surgical resection is still the most effective treatment for pancreatic cancer, but the surgical resection rate is less than 20%, and the postoperative complication rate is high. Since the early diagnosis rate of pancreatic cancer is less than 5%, it is prone to early infiltration and metastasis (distant organs and lymph node metastasis), and neurophilic infiltration is the unique biological behavior of pancreatic cancer and the main cause of incomplete surgical resection and postoperative recurrence. Therefore, improving the early diagnosis of pancreatic cancer and enhancing standardized comprehensive treatment are the focus of pancreatic cancer research, and we are now carrying out combined pancreatic peripheral nerve resection to expand the resection of pancreatic cancer, which has significantly improved the 5-year survival rate. Chemotherapy is available for pancreatic cancer that cannot be removed surgically or to prevent recurrence after surgery. Chemotherapy for pancreatic cancer is expected to reduce the incidence of cancer recurrence and metastasis after surgery. Current gemcitabine-based combination chemotherapy regimens have been shown to have a positive impact on improving survival in patients with pancreatic cancer after surgery, with a median survival time improvement of approximately 6 months. Pancreatic cancer is a tumor with low sensitivity to radiotherapy. Due to the deep location of the pancreas, the surrounding gastrointestinal, liver, kidney and spinal cord are less tolerant to radiation, which is unfavorable to radiation therapy for pancreatic cancer. However, in recent years, with the development of intraoperative radiotherapy and treatment planning under CT precise positioning and multifield extracorporeal radiotherapy, radiotherapy has become one of the main means in the treatment of pancreatic cancer. In postoperative and inoperable advanced pancreatic cancer, radiotherapy alone has no significant effect on the survival of patients. Combined radiotherapy and chemotherapy, on the other hand, can effectively relieve symptoms, reduce pain, improve the quality of survival, and prolong survival.