Weakness of limbs and generalized weakness may be caused by overexertion, but it may also be caused by cold, depression, or rheumatic immune diseases. You should first pay attention to rest, and if it cannot be relieved after rest or accompanied by other symptoms, you need to promptly consult a doctor for relevant examination and treatment. I. Physiological factors: engaging in overly heavy physical work, strenuous exercise, overwork, or often staying up late and working overtime may cause excessive fatigue, resulting in weakness of the limbs and general weakness. Usually no special treatment is needed, and the symptoms will gradually ease after a period of rest. During this period, attention should also be paid to appropriately reduce the number of exercises and increase sleep time, so as to improve discomfort. Pathological factors: 1, cold: especially influenza, usually caused by viral infection of the upper respiratory tract, can lead to fever, cough, nasal congestion, runny nose and other symptoms, some patients will also appear weakness of the limbs, generalized weakness. It is necessary to follow medical advice to use antiviral drugs, as well as antipyretic and analgesic drugs for treatment, such as antiviral oral solution, ibuprofen, etc.; 2, depression: is a relatively common neuropsychological disorders, such patients may have long-term depressed mood, listlessness and other symptoms, may also appear symptoms of physical abnormalities, such as weakness of the limbs, generalized weakness, dry mouth, blurred vision, etc., and physical examination without obvious abnormalities. Such patients need to take oral antidepressants, such as fluoxetine hydrochloride tablets and sertraline hydrochloride tablets under the guidance of a doctor, and the symptoms can be improved after medication; 3. Other causes: such as hypoglycemia, hypokalemia, rheumatic immune diseases, may also lead to weakness of the limbs and general tenderness, which need to be treated for the original disease. If it is hypoglycemia, you can take some sugar cubes and so on to relieve it. If the symptoms are serious or not relieved, you need to treat with intravenous glucose and so on under the guidance of doctors.