Bile reflux should be treated with medication, including the following: 1, promote gastrointestinal motility drugs, common drugs are mainly morpholine, etc.; 2, oral gastric mucosa protection drugs, such as Daxi; 3, acid suppression therapy, acid suppression therapy including H2 receptor blockers and proton pump inhibitors, including Ranitidine, Loxacol, etc. for treatment; 4, check whether there is H. pylori, if there is H. pylori treatment is required. In general, bile reflux should be treated with medication in addition to diet. If medication is not effective and bile reflux is very serious, surgery is not excluded.