The nine-valent vaccine generally refers to the HPV nine-valent vaccine, which can prevent about 90% of cervical cancers for those who have completed effective vaccination according to the prescribed vaccination schedule, so to ensure the effectiveness of the vaccine, patients are advised to complete all vaccination within 6 months. For vaccinees who are in good health and have no obvious adverse reactions, the vaccination usually needs to be completed within 6 months. In case of unexpected circumstances such as accidents, bad weather, forgetfulness, etc., the vaccination should be made up within 1 month to avoid affecting the effect of the vaccine, and the doctor should judge whether the vaccination can be continued for those who have been made up for more than 1 month. The main adverse reactions of the nine-valent vaccine are local symptoms such as swelling and pain at the injection site, rash and itching, as well as systemic symptoms such as headache, dizziness, fever, nausea, vomiting and fatigue. If the adverse reactions worsen during the interval, or if pelvic inflammatory disease or vaginitis occurs, as well as allergic diseases and various acute diseases, it is recommended that the vaccination be cured first or be carried out after the condition has stabilized to avoid aggravating the adverse reactions of the vaccine. It is also recommended that those who are pregnant or breastfeeding should receive the vaccination first. It is also recommended that women who are pregnant or breastfeeding delay vaccination. In summary, it is recommended that the nine-valent vaccination be completed within 6 months, but in view of unexpected factors and the patient’s physical condition, if the vaccination cannot be given on time or the normal vaccination date has been missed, the doctor can promptly consult the doctor to determine whether the vaccination needs to be replenished or postponed immediately.