Fever in liver nodule is not necessarily due to advanced stage of liver cancer, but may also be due to secondary infection as well as liver cysts and other diseases. 1. Advanced stage of liver cancer: Liver cancer is a kind of liver nodule, which is a malignant transformation of liver cells leading to occupying lesions in the liver. In the advanced stage of liver cancer, persistent fever, jaundice, nausea and vomiting will occur. 2. Secondary infection: when liver nodule patients suffer from secondary infection of liver and biliary system, upper respiratory tract infection, etc., it may also lead to fever. Therefore, fever of liver nodule is not necessarily advanced stage of liver cancer. 3. Liver cyst: Liver cyst is a relatively common liver disease, which refers to the occupying lesion in liver with fluid accumulation. At this time, when the cyst fluid in the cyst becomes infected, there is a possibility of generalized fever. Therefore, when the symptoms of fever in liver nodule appear, you should go to the hospital in time to improve the examination, clarify the diagnosis and carry out regular treatment.