High immunoglobulin A is commonly found in autoimmune diseases, infectious diseases, etc., which need to be further investigated and treated with targeted drugs and other treatments. 1. Autoimmune diseases: patients with autoimmune diseases such as systemic lupus erythematosus and dermatomyositis will have high immunoglobulin A. According to different types of diseases, they need to choose glucocorticosteroids such as prednisone and dexamethasone, or non-steroidal anti-inflammatory drugs such as ibuprofen and etoricoxib to carry out drug treatment. 2. Infectious diseases: immunoglobulin A is involved in the body’s immune response, so when the patient’s body exists in the urinary tract infections, upper respiratory tract infections and other diseases will lead to high immunoglobulin A. This situation needs to be based on different causes of the selection of antibiotics for the treatment of the appropriate, such as cephalosporins, penicillins and so on. Drugs need to be used under the guidance of a physician, high immunoglobulin A may have other reasons, it is recommended that patients with high immunoglobulin A to the rheumatology and immunology department of the regular hospital for detailed consultation, and comply with the doctor’s instructions for standardized treatment.