For closed pimples, also known as closed acne, it is recommended to use retinoic acid drugs, such as retinoic acid cream, viamine ester Vitamin E cream, adapalene gel, tazarotene gel and so on, the above drugs are required to be used at night, and need to be avoided after use, otherwise it will stimulate the skin to redness, the adverse reaction, and must be a small amount of topical application. If the area of the rash is large, you can also take oral retinoid drugs, such as isotretinoin and viamin capsules, but must be taken under the guidance of a doctor, as the above drugs can cause high blood fat or have an effect on liver function. At the same time, pregnant women are not allowed to take, retinoids have a teratogenic effect. For acne patients can also go to the regular hospital, for fruit acid chemical skin resurfacing treatment, while eating more fresh vegetables, fruits, avoid picking.