Toothache medication does not work needs to be treated accordingly to the cause of the disease, such as dental fillings, root canal therapy, peri-coronary rinsing and other operations. Toothache is most often seen in bacterial infection caused by nerve pain, toothache when taking medicine is not obvious, need to carry out dental treatment to relieve. 1. Dental caries: It is necessary to remove the decayed bacterial infected part, if the nerve is not exposed, it can be filled directly. 2. Pulpitis: If the nerve is infected and there is pain from hot or cold stimulation, pain at night when sleeping, or pain that cannot be localized throughout the mouth, the nerve needs to be removed for root canal treatment. After root canal treatment the tooth becomes brittle and splits easily. Crown restoration is recommended. 3. Wisdom tooth pericoronitis: inflammation of the gums around the wisdom tooth causes pain, and local rinsing and medication can be lifted. Not all toothaches require medication. Toothache should be timely consultation hospital stomatology, identify the cause of the disease, symptomatic treatment, in order to alleviate the pain.