Antibiotics can not kill fungi, antibiotics fungicidal mechanism mainly through the inhibition of bacteria in the body, cell wall synthesis and play the role of fungal inhibition. Commonly used are β-lactams, macrolides, lincomycin, peptides and quinolones antibiotics. Fungi are widespread in the surrounding area and can cause disease when the immunity of the body is low or when a large number of antibiotics are applied for a long time, causing dysbiosis. Fungal infection is divided into superficial fungal infection and deep fungal infection, the use of antifungal drugs, clinically commonly used are fluconazole, amphotericin B, etc. Therefore, antibiotics can not kill the fungus, kill the fungus must be antifungal drugs.