Mastectomy and drainage may lead to nipple inversion. Mastectomy and drainage is often used in the treatment of acute mastitis forming breast abscess, when the abscess is formed, it needs to be punctured and aspirated under ultrasound guidance in time, and if necessary, it can be incised and drained, and the abscess in the areola part should be made along the edge of the areola to make a curved incision, and the deep abscess of the breast or the posterior abscess of the breast can be made along the lower edge of the breast to make a curved incision. If the breast disease invades the ligaments, ducts, and fascia of the breast, causing the invaded ducts, ligaments, and fascia to contract, or invades the above mentioned tissues when performing an incision and drainage procedure, it may lead to nipple inversion. In addition, breast cancer can also lead to nipple inversion. Cancer adjacent to the nipple or areola shortens the milk ducts by invading them, which may pull the nipple to the side of the cancer, and then cause the nipple to retract and become concave. If nipple inversion occurs after mastectomy and drainage, patients should find out the cause of the disease under the guidance of doctor and treat it in time.