Bilateral subpleural lesions usually refer to the bilateral pleura due to various causes such as pleural inflammation, chronic pleural thickening, or pleural nodules, which need to be treated promptly once detected. The pleura can be divided into the dirty pleura, which is the fibrous membrane on the surface of the lungs, and the mural pleura, which is the fibrous membrane on the inner side of the chest wall. The so-called bilateral subpleural lesions usually include pleural inflammation, chronic pleural thickening, or pleural nodules, etc. The so-called bilateral subpleural lesions are usually caused by various types of infections, such as bacterial infection, chronic pleural thickening, or pleural nodules. Various types of infections such as bacterial, fungal, viral, parasitic and other pathogens caused by infection, trauma, malignant tumors, autoimmune diseases can cause pleural inflammation, chronic pleural thickening is commonly seen in prolonged pyothorax and Mycobacterium tuberculosis infections, and pleural nodules are mostly caused by various infections that involve the pleura, primary or metastatic pleural tumors. Patients with subpleural lesions in both lungs should consult a doctor in time to find out the cause of the disease and follow the doctor’s instructions to treat the cause and symptoms.