SLE is a chronic autoimmune disease with multi-system and multi-organ damage, which can threaten patients’ health and even shorten their life span. In the past, due to insufficient knowledge of this disease, early diagnosis and early treatment were not possible, resulting in some patients with SLE being critically ill, losing the time for treatment and even endangering their lives; however, nowadays, with the development of medical technology, the understanding of this disease is gradually deepened, and the prognosis of this disease However, with the development of medical technology and better understanding of the disease, the prognosis of the disease has been significantly improved, and the average survival of patients is much longer than before. SLE can cause different degrees of damage to several organs of the body and can damage the physiological functions of multiple systems such as immune, digestive, blood and kidney systems. SLE was once considered a high mortality disease, and in the 1950s, the 4-year survival rate of SLE patients was only 50%. However, since glucocorticoids and immunosuppressants have been used in the treatment of SLE, the 10-year survival rate of SLE patients has now exceeded 90% and the 15-year survival rate can reach 80%. With comprehensive and standardized treatment, most patients can work, live, marry and have children like normal people. It should be noted that the clinical manifestations of SLE are complex and diverse, and the severity of the disease varies from patient to patient. For patients with acute onset, rapid disease progression, and heavy lupus or lupus crisis with severe damage to several important organs, the disease is more dangerous and is the main cause of long-term death in lupus patients. Therefore, the prognosis of SLE patients has been greatly improved with the intensive research in modern immunology, the emergence of new therapeutic drugs, and the enhancement of patient education and management strategies. Most SLE patients, after early diagnosis and systematic and standardized treatment, have a substantially improved quality of life and a substantially longer average survival period.