At present, there are many types of hypoglycemic drugs used in clinical practice, and the side effects of each type of drug are different, so there is no such thing as which hypoglycemic drug has the least side effects. The most suitable drug should be chosen according to the patient’s specific condition, adverse reactions, etc. Common drugs include metformin, alpha-glucosidase inhibitors, sulfonylurea hypoglycemic drugs, etc. 1. Metformin: Commonly used drugs include metformin, which is mainly applicable to patients with type 2 diabetes mellitus, especially those who are overweight. Common adverse reactions are mainly gastrointestinal reactions, such as nausea, vomiting, abdominal distension, etc.; prohibited in patients with hepatic and renal insufficiency, serious infections. 2. α-glucosidase inhibitors: a common drug is acarbose, which is mainly applied to diabetic patients with high postprandial blood glucose. Common bloating, increased gas and other adverse reactions; prohibited in patients with chronic gastrointestinal dysfunction, hepatic and renal insufficiency and other patients with obvious digestion and absorption disorders. 3. Sulfonylurea hypoglycemic drugs: common drug is glimepiride, which is suitable for patients with type 2 diabetes mellitus who cannot satisfactorily control sugar with diet control, exercise therapy and weight reduction. Common hypoglycemic reaction, gastrointestinal discomfort and other adverse reactions; type 1 diabetes, ketoacidosis, diabetic coma is prohibited. Glucose-lowering drugs need to be used under the guidance of a doctor, not blindly self-administered.