Taking medication for advanced prostate cancer will have some effect on kidney, but it usually does not cause serious damage under medical advice, mainly aggravating the burden of kidney, which needs to be closely observed. Advanced prostate cancer needs regular application of chemotherapeutic drugs, endocrine therapy drugs and so on. Commonly used drugs include docetaxel, goserelin and flutamide. The corresponding drugs usually do not directly cause kidney damage, but the drugs will be metabolized by the kidneys, which will increase the burden on the kidneys, and regular blood tests of renal function are still needed during the period of using the drugs. During the use of medication for advanced prostate cancer, once there are obvious symptoms such as abnormal urination and hematuria, it is necessary to consult a doctor in time for observation, and after confirming the diagnosis of the disease, carry out standardized treatment under the guidance of the clinician, so as to avoid the delay of the disease.