What happens to high-grade squamous epithelial lesions on cervical biopsy?

Cervical biopsy results will generally be of three types, one for chronic cervicitis, one for low-grade intraepithelial neoplasia, and one for high-grade squamous intraepithelial neoplasia. When high-grade squamous intraepithelial neoplasia is present, it suggests the possibility of precancerous lesions. This is because prolonged viral interference can cause cervical lesions that can lead to cancer. In such cases, first of all, cervical conization surgery, including laparotomy, should be performed to remove part of the cervix for pathological examination to see the extent of infiltration. If the degree of infiltration is deeper, it is determined to be cervical cancer. If the degree of infiltration is not deep, there may be chronic inflammation, which means that the problem is not serious and local conization can be performed. In case of cervical cancer, extensive total hysterectomy, including bilateral adnexal and lymph node dissection, and postoperative radiotherapy and chemotherapy are required.