The primary cause of stenosis occurring in the left anterior descending branch is coronary atherosclerosis. The main cause of left anterior descending stenosis is atherosclerosis of the coronary arteries, which leads to narrowing of the blood vessels and the formation of atherosclerotic heart disease. The etiology of coronary atherosclerosis is currently considered to be a combination of multiple adverse cardiovascular risk factors on the basis of genetic predisposition, including hypertension, hyperlipidemia, diabetes mellitus, and smoking. The left anterior descending branch is a very important blood vessel down the left main stem of the coronary artery, which is the main blood vessel for myocardial nourishment. Stenosis of the left anterior descending branch can lead to ischemia of cardiomyocytes in the apical portion of the heart, the anterior septum, the anterior wall of the left ventricle, and the inferior lateral wall, and even myocardial infarction. Coronary artery disease can be diagnosed when the degree of stenosis of the left anterior descending branch of the coronary artery exceeds 50%. For patients with stenosis of the left anterior descending branch of the coronary artery, it is recommended to consult the Department of Cardiovascular Medicine of a regular hospital.