What is mother-to-child interruption? Pregnant women with hepatitis B or pregnant women who are asymptomatic hepatitis B carriers (regardless of whether they are triple positive or triple positive, but with positive HBV-DNA) can undergo mother-to-child interruption, which is a combination of prenatal and postnatal interventions to immunize infants with both active and passive immunizations. The implementation of this program can effectively block the transmission of hepatitis B virus from mother to baby. Sun Changyu, Department of Infectious Diseases, First Affiliated Hospital of Zhengzhou University The conventional preventive method is to vaccinate newborn babies against hepatitis B. It has been proved that this method can only block 70% of the mother-to-child transmission, and does not have the effect of blocking the intrauterine infection of infants with hepatitis B. Therefore, this passive blocking method can be used to prevent the transmission of hepatitis B virus from mother to baby. Therefore, this passive blocking method makes more than 400,000 newborns still carry hepatitis B virus at birth. Mother-to-child blockade: From the 28th week of pregnancy, pregnant women receive a monthly injection (100-200μ) of hepatitis B immunoglobulin. Infants are vaccinated with Hepatitis B immunoglobulin at 0 and 2 weeks of birth, and then one injection of Hepatitis B vaccine one month after birth; this active + passive vaccination method can achieve ideal results. How to use hepatitis B vaccine effectively The HBSag genetically engineered vaccine currently applied in our country plays an ideal role in the prevention of hepatitis B. However, attention should be paid to the vaccination method, according to the procedure of 0, 1, and 6 months, and three injections. Injection route: there are intramuscular, subcutaneous and intradermal injections, but does not advocate intramuscular injection of the buttocks. Precautions: Blood is drawn 1-3 months after the third injection to check whether anti-HBS is produced. It is worth mentioning that a small number of people do not have anti-HBS after three injections of hepatitis B vaccine, which is a non-responsive reaction, generally not more than 10%, and this kind of people can be strengthened by increasing the number of times of vaccination or increasing the dose of vaccine. Is everything safe after vaccination? Very few children do not develop anti-HBS after hepatitis B vaccination, or develop hepatitis B even though they develop a high titer of anti-HBS. This is due to infection by a mutated strain of hepatitis B virus (mutation of the gene in the s region of the HBV), and the previous anti-HBS is ineffective against the new mutated strain. Should the hepatitis B vaccine be revaccinated After vaccination, the anti-HBS level in the vaccinated person gradually decreases over time, but when they are exposed to HBV shock, the antibody can rise again due to the immune memory effect. However, 5-10% of the vaccinated do not produce anti-HBS or produce low levels of anti-HBS. Those with anti-HBS of 100-1000iu/l should be booster vaccinated after 2-4 years. Those with anti-HBS >10,000iu/l can repeat the anti-HBS level after 4-6 years to decide whether to boost vaccination. Hepatitis B, also known as serum hepatitis and viral hepatitis B (hepatitis B), is an infectious disease caused by hepatitis B virus (HBV). It is transmitted through blood and body fluids and has a chronic carrier state. Because it may be transmitted through sexual life, it is internationally included in sexually transmitted diseases. The disease is widely prevalent in China, with a high rate of infection in the population, reaching more than 35% in some areas. According to the relevant data, the number of patients who have tested positive for hepatitis has reached 189 million, while the number of people who should be diagnosed but are not (carriers) is nearly 400 million.