Congenital megacolon, also known as intestinal ganglion cell-free disease, is a common congenital intestinal malformation in children because of the lack of ganglion cells in the rectum or distal colon, which prevents normal peristalsis and causes fecal stagnation in the proximal colon, resulting in hypertrophy and dilatation of the intestinal segment. It is a common congenital intestinal malformation in children. Children often exhibit delayed fecal excretion and persistent constipation and bloating. Long-term bloating and constipation can cause decreased appetite and malnutrition in children. A common complication of congenital megacolon is small bowel colitis, which is characterized by recurrence or worsening of abdominal distension and constipation, and in some cases, fever, diarrhea and vomiting. At present, the morbidity and mortality rate of congenital megacolon combined with small bowel colitis in newborns is still high. Therefore, once congenital megacolon is diagnosed, proper bowel cleansing should be started as soon as possible to reduce the accumulation of feces and bacterial growth in the intestine. At the same time, feeding conditions should be improved to enhance the child’s own immunity and prevent the occurrence of small bowel colitis. Before surgery, children should eat a low-sludge diet high in energy, protein, vitamins, and easy to digest, and avoid foods that cause flatulence such as thick soy milk and indigestible foods such as nuts, dried beans, and large vegetables. Under the condition that the effect of bowel cleansing is exact and the stool is expelled smoothly, various kinds of refined grains, eggs, fish, lean meat, melons and fruits with little fiber content and milk should be encouraged to eat in order to obtain sufficient nutrition. Processing according to the age of the month and the degree of acceptance of the child, infants under one year of age should be chopped and boiled soft to ensure smooth ingestion and easy digestion. Supplemented with bowel cleansing to expel as much stool as possible from the body each day. For infants under 4 months of age, breastfeeding is encouraged, and if the amount of breast milk is not enough, infant formula is added. 4 to 6 months, if digestion is good and stools are discharged smoothly, complementary foods can be added, and iron-containing baby rice paste, vegetable puree, fruit puree, egg yolk puree and tofu puree are added gradually, with one complementary meal per day and the rest still drinking milk, so as to give babies balanced nutrition, prevent iron-deficiency anemia and strengthen their immunity. From 7 to 9 months, you can add congee, rotten noodles, fish puree, liver puree and other foods, the production still needs to be fine, and gradually reduce the number of milk meals. 10 to 12 months onwards, you can try to eat soft rice, minced vegetables, minced meat, etc. Supplementary food should be added gradually, from less to more, from thin to thick, from coarse to fine, from one to many, do not be too hasty, counterproductive. If your baby has fever, diarrhea, constipation and other discomforts, you should suspend the addition of complementary foods, and continue after the symptoms disappear. Parents should weigh their babies at least monthly and consult a nutritionist regularly. If the baby’s weight gain is good and the physical examination is up to standard, radical megacolon resection is feasible. In addition to paying attention to cleanliness and keeping the perianal skin dry, parents should eat easily digestible food and avoid flatulent, rough, dry and hard food. In the early stage, milk, porridge and other fluids can be chosen. After the intestines adapt, the diet can be gradually approached to the daily diet according to the age stage, with reference to the principles mentioned above. To prevent the recurrence of postoperative constipation, babies who have adapted to complementary foods can eat foods rich in dietary fiber, such as sweet potatoes, potatoes, knapweed, black fungus, kelp, plantain, apples, kiwi, etc. Those with poor nutritional status or long-term hospitalization should be properly supplemented with enteral nutrition preparations and vitamins and other micronutrients, as recommended by the nutritionist. Parents should follow up regularly to track the growth and development of the child and adjust the diet plan in time.