There are many reasons why you can’t sleep with sore and swollen calves, such as over-exercise, lumbar disc herniation, varicose veins, and so on. 1. Excessive exercise: Excessive exercise and sports, especially a sudden large number of sports, will lead to the accumulation of lactic acid in the body, causing the calf soreness and swelling obvious, unable to sleep. High-intensity, strenuous exercise can cause strain and injury to the calf muscles, thus causing calf soreness and inability to sleep. 2. Lumbar disc herniation: When the herniated disc nucleus pulposus compresses the nerve root, it will radically cause soreness and pain in the calf, which affects the ability to sleep. 3. Varicose veins: patients with varicose veins in the lower limbs have obstacles to local blood circulation, and after standing or walking for a long time, they will have symptoms such as soreness and swelling of the affected limbs, easy fatigue, and cramps in the calf muscles. There may be other reasons for calf soreness and swelling, such as osteoporosis, lumbar spinal stenosis, vasculitis, etc. It is recommended to go to the hospital in time to improve the examination and to clarify the cause of the disease.