It may be a physiological developmental variant and is neither a tumor nor a venereal disease. The clinical manifestations are white, skin-colored or light red papules that do not fuse with each other and are arranged in one or several rows along the coronal sulcus at the posterior margin of the glans. It is commonly known as “glans pearly whites”. In medicine, it is named as pearly penile papulosis. Medical experts have confirmed that the structure is normal connective tissue hyperplasia after performing pathological biopsy. Routine tests include blood tests and physical examination. The main point of the diagnostic examination of penile pearlescent rash is that the damage is confined to the edges of the glans, the number of damage is high, it is pearly milky white papules with a smooth surface, the damage does not increase with the duration of the disease and the acetic acid test is negative. Histopathological examination reveals concave hollow cells. Often young men they are worried, some worry about growing a tumor, some are afraid of getting a sexually transmitted disease. In the sexual medicine consultation letters, there are not a few who ask about this lesion, and they describe it very specifically: the rash is the size of a small rice grain, similar in color to the surrounding skin, not painful or itchy, and although it does not affect urination or sexual life, the psychological pressure is very high. The disease does not have any effect on health or the physical function of the penis. The most important thing for those who suffer from this disease is to recognize the disease and free themselves from fear and worry.