Whether gallbladder wall thickening of 8mm is serious or not depends on the cause. Thickening of the gallbladder wall due to edema caused by acute cholecystitis is not serious; however, thickening of the gallbladder wall by 8mm due to gallbladder stones with cholecystitis is more serious because of the risk of gallbladder cancer. 1. Acute cholecystitis: the edema of gallbladder wall due to inflammation stimulation leads to the thickening of gallbladder wall by 8mm, which can be treated promptly with antibiotics such as levofloxacin and cefaclor for anti-infective treatment, and the edema of gallbladder wall disappeared after the inflammation subsides, which is generally not too serious, and the wall of the gallbladder may be restored to normal. 2. gallbladder stones with cholecystitis: the gallbladder is in a state of chronic inflammatory stimulation for a long time, such as stones, may also lead to the gallbladder wall thickening 8mm, this thickening is irreversible, and may also increase the risk of gallbladder cancer, this is a more serious situation. Because of the gallbladder wall thickening 8mm, you should go to the hospital in time to improve the examination, clear the cause of the disease and then give targeted treatment.