Vitamin B12 is not generally used in the treatment of insomnia, but is mainly used in the treatment of neurotrophic dysfunction, such as peripheral neuritis, peripheral neuropathy, myelopathy, patients with sensory disorders can be applied, but also can be used in cerebrovascular disease caused by sensory disorders. Insomnia is mainly treated with sedation, and lorazepam, eszopiclene and alprazolam can be taken orally in severe cases. If the insomnia is mild and short-lived, neuromodulatory drugs such as ghrelin, tranquilizer and blood and brain granules can also be used. It can also be intervened through lifestyle, such as developing a good routine, go to sleep and wake up on time, do not stay up late, avoid excessive excitement before going to bed, avoid coffee and strong tea, can be appropriate aerobic exercise, a cup of hot milk before going to bed, all help to improve sleep.