Two types of tumors are included, each associated with the presence of fusion genes for two transcription factors (TFE3 and TFEB). xp11 translocation causes fusion of the TFE3 gene; t(6;11) causes MALAT1-TFEB fusion. This tumor is more common in childhood and accounts for only 6% to 4% of adult-onset renal cell carcinomas. t(6;11) renal cell carcinomas are less common than Xp11-translocated renal cell carcinomas. It is largely non-characteristic. Microscopically, Xp11-translocated renal cell carcinoma appears as a papilla formed by clear cells with scattered sand-like calcifications, whereas t(6;11) translocated renal cell carcinoma appears as a nest of cells of both sizes with basement membrane-like material deposited within. Immunohistochemistry showed decreased expression of epithelial markers such as CK, EMA, PAX8 and other tubular markers; Xp11 renal cell carcinoma: partial expression of melanin markers and TFE3; t(6;11) renal cell carcinoma showed constant expression of melanin markers such as HMB45, Melan A and Cathepsin K, TFEB. The fusion gene of TFE3 or TFEB was detected by FISH.