After the recurrence of follicular lymphoma, it depends on the site of recurrence, the time since the last treatment, and whether there is any transformation to high-grade lymphoma, and so on, to make a comprehensive judgment. If it is a distant metastatic recurrence, chemotherapy or local radiotherapy can be re-done. If it is a high-grade transformation, if the original follicular lymphoma is grade I-II, and now it has transformed into diffuse large B-cell lymphoma, it can be re-warmed to diffuse large B-cell lymphoma with immunotherapy and chemotherapy. If the original low-grade follicular lymphoma is still present, it can still be treated with the original treatment regimen, and autologous stem cell transplantation can also be done after achieving complete remission with chemotherapy. In conclusion, after the recurrence of follicular lymphoma, it is necessary to make a comprehensive judgment according to the site of recurrence, the type of pathology after recurrence, and the original treatment means.