The pain in the calf bone after exercise may be due to over-exercise, or accidental injury during exercise, or there may be lesions in the calf bone itself, such as bone cysts, osteochondroma or osteomyelitis. It is recommended to go to the orthopedic department of the hospital in time to see a doctor for a preliminary judgment combined with physical examination, and routinely improve the calf X-ray examination to understand whether there are obvious abnormalities in the bones, and then do the corresponding treatment according to the examination results. The pain of calf bones caused by exercise and overexertion should be relieved by more rest and appropriate hot water; bone cysts, osteochondroma and other lesions can be removed by local surgery, and pain can be relieved by appropriate painkillers, such as Lupin toine extended-release tablets.