The presence of frequent and heavy stools during quadruple therapy may be an adverse reaction to the treatment. This is an adverse symptom caused by an imbalance in the intestinal flora. Quadruple therapy needs to be taken under the supervision of a specialized doctor. Quadruple therapy is a treatment to eradicate H. pylori. It mainly consists of four medications, including acid-suppressing drugs (such as omeprazole, etc.), bismuth preparations (such as bismuth pectin, etc.), and the anti-infective drug metronidazole + clarithromycin. Most people will not experience adverse reactions, and only a small percentage will experience adverse reactions such as increased bowel movements due to imbalance of intestinal flora. The symptoms improve when the medication is stopped. It should also be noted that when taking the quadruple therapy, you need to eat a light diet, avoid spicy, greasy and other stimulating foods to avoid the adverse reactions of increased bowel movements caused by improper diet. It is recommended that patients actively go to the hospital for consultation, clear diagnosis, and use medication under the doctor’s instructions, do not take medication on your own, so as not to delay the condition.