There is no such thing as “what is the best medicine for gout”. Gout needs to be based on the uric acid level, the underlying disease, previous drug allergies and other choice of therapeutic drugs, generally non-steroidal anti-inflammatory drugs, small dose glucocorticoids, inhibitors of uric acid production and promote uric acid excretion of drugs and so on. Gout is a metabolic disease with acute arthritis, chronic arthritis, gouty stone and gouty nephropathy on the basis of hyperuricemia. Gout requires uric acid-lowering therapy on an anti-inflammatory basis. In gout acute arthritis attack or uric acid lowering the initial prevention of gout attack, need to choose colchicine, non-steroidal anti-inflammatory drugs such as ibuprofen, etc., glucocorticoids such as low dose prednisone and other anti-inflammatory analgesic treatment. Gout patients need to actively control uric acid, uric acid-lowering drugs include inhibitors of uric acid production such as allopurinol, febuxostat, and promote uric acid excretion such as benzbromarone. However, if there is HLA-B5801 gene positive, can not choose allopurinol class of drugs; if there are cardiovascular disease risk factors, the choice of febuxostat need to be careful; if there are kidney stones, it is not recommended to prefer benzbromarone. Therefore, the treatment of gout needs to be under the comprehensive assessment of the specialist to choose the appropriate program, there is no such thing as the best drug. There is no such thing as the best medication for gout. It is still recommended to consult a regular hospital in a timely manner for gout.