Patient Female 64 years old With recurrent cough and white mucous sputum for one year, she visited several hospitals and was repeatedly examined with chest radiographs (anterior and posterior), but no clear diagnosis was made, and she was given antimicrobial therapy and symptomatic treatment. Her cough symptoms did not improve significantly. In November 2005, he felt pain in the left lower limb when moving and the symptoms worsened when walking, and was given symptomatic treatment. On the 15th, the patient was found by his family in the morning to be in a faint state of consciousness, with deviated lips and slurred speech. He was sent to hospital urgently for examination, and was found to have multiple metastatic tumors in his mind by CT examination of the mind, and then CT examination of the chest, which revealed a tumor in the left lower lung, whose diameter was about 2*1.5cm, and bone scan of the whole body, which revealed metastatic foci in the left hip joint. At that time, the diagnosis was clear: left lower lung cancer with multiple metastases (brain, bone, etc.). The diagnosis was clear, dehydration, symptomatic, treatment was given, and chemotherapy was applied at the same time (from the PS score, the patient was not suitable for chemotherapy, but the patient’s family members all strongly requested to give chemotherapy), and the chemotherapy regimen was chosen from drugs with less toxic effects. After 1 cycle of chemotherapy, the patient’s left lower limb pain symptoms subsided, after 2 cycles of chemotherapy, the patient’s brain metastases shrunk significantly and cerebral edema was reduced significantly, after 3 cycles of chemotherapy, the patient’s brain metastases were in complete remission (CR), and the patient underwent a total of 4 cycles of chemotherapy. The patient recovered well, but on chest CT, the tumor was in partial remission (PR). Six cycles of chemotherapy were planned, but for other non-medical reasons, the patient did not complete chemotherapy as discussed. In the 7th month after chemotherapy, another cerebellar metastasis (1 metastasis) occurred, which showed unstable gait when walking, and surgery (removal of cerebellar metastasis) was recommended, followed by targeted therapy. The patient survived well with targeted therapy for 4 years (survival with tumor). Subsequently, the patient stopped the targeted therapy drugs on his own, and 3 months later, he developed brain metastasis again and was operated again. After surgery, he continued to take targeted therapy drugs and is now recovering well in general. Normal living condition. Experience and lessons learned: 1. Patients should consult their physicians more often for treatment. 2. Standardized treatment for lung cancer patients is extremely important. 3.Late stage lung cancer should also be actively treated in order to obtain good treatment effect. 4.Rational treatment can make patients get more benefits. 5.Personalized treatment for lung cancer is currently recommended by experts and professors, and it is also the trend of lung cancer treatment in the future. 6.Personalized treatment is an economic and effective treatment method.