Doxycycline still has some non-dosing reactions. Doxycycline can be deposited in the teeth and bones, resulting in varying degrees of tooth discoloration, yellow staining, enamel dysplasia, and can lead to bone dysplasia. Damage to the liver: High doses of doxycycline can cause damage to the liver, usually hepatic steatosis. Side effects on the gastrointestinal tract include anorexia, nausea, vomiting, diarrhea, tongue inflammation, and difficulty swallowing. Side effects against the skin include maculopapular rash, maculopapular rash, and erythema. There is also nephrotoxicity, often with elevated creatinine. Very few patients may have hypersensitivity reactions, such as rubella, angioneurotic edema, allergic reactions, allergic purpura, pericarditis, and exacerbation of lupus erythematosus symptoms. Inside the hematological system, there can be hemolytic anemia, thrombocytopenia, neutropenia, etc.