A large, fat tongue with teeth marks can be seen in lingual inflammation, angioneurotic edema, tongue tumor and other conditions. 1. Tongue inflammation: when suffering from micronutrient deficiencies, bacterial or fungal infections and other undesirable conditions, there can be inflammatory manifestations such as swelling and pain in the tongue. 2. Angioneurotic edema: mainly caused by peanuts, seafood and other foods, penicillin, aspirin and other drugs or pollen, dust and other substances caused by allergic reactions, the patient in addition to the swelling of the tongue, can be accompanied by generalized itching of the skin, rashes and other symptoms. 3. Tongue tumor: if suffering from benign tumors such as fibroma of tongue or malignant tumors such as squamous cell carcinoma, the tongue body may be enlarged due to tumor hyperplasia and accompanied by teeth marks. It is recommended that patients suffering from tongue hypertrophy and other abnormalities should go to the hospital in time and actively cooperate with doctors for diagnosis and treatment.