Cholera is an acute gastrointestinal infection caused by Vibrio cholerae of serogroups O1 and O139. Generally there are symptoms such as diarrhea, vomiting and dehydration. 1. Diarrhea: Vibrio cholerae reproduces in large numbers in the digestive tract, stimulating the intestinal tract and causing diarrhea. It is often the first symptom, usually painless and severe diarrhea. The feces are muddy or watery and visible. Soon turn to rice slop-like stool or wash meat-like blood stool, no fecal matter, the number of stools gradually increase, several times a day to more than ten times a day, serious patients directly out of the anus, each time the amount of stool more than 1000 ml, there is no fecal taste, a little fishy smell. 2. Vomiting: due to the exotoxins of pathogenic bacteria stimulate the gastrointestinal tract, the symptoms of vomiting, usually occurring after diarrhea, mostly without nausea, jet vomiting. The vomit is initially gastric contents, then watery, and in severe cases, rice-slop-like liquid, similar to feces, may be vomited. In mild cases, there may be no vomiting. 3. Dehydration: As a result of severe diarrhea and vomiting, a large amount of water is lost and symptoms of dehydration appear, which may be manifested by slightly dry skin and mucous membranes and slightly less elastic skin. In severe cases, there is sunken eye sockets, mild hoarseness, decreased blood pressure, and decreased urine output. In addition, muscle cramps, low blood potassium, acidosis, etc. may also occur. When the above symptoms occur, it is recommended to consult a doctor in time, follow the doctor’s instructions for further examination, clarify the cause with the doctor’s help, and carry out targeted treatment or therapy.