Shouting in the later stages of Parkinson’s disease may be caused by severe deterioration of the disease and psycho-cognitive changes. Parkinson’s disease, also known as tremor paralysis, is a common degenerative neurological condition in middle-aged and elderly people, resulting in a decrease in dopaminergic neurotransmitters due to degenerative loss of the nigrostriatal dopaminergic nervous system, leading to a predominantly dyskinetic condition. Once the onset of Parkinson’s disease, the condition gradually aggravated, progressing more and more quickly, late-stage Parkinson’s patients are very painful, can appear mental cognitive impairment, accompanied by anxiety, irritation, depression and other adverse emotions, but also can appear intellectual decline, action can not, speech can not, can not take care of their own symptoms, some patients can appear blackout daytime shouting phenomenon. Parkinson’s disease patients should seek timely medical treatment and active treatment when the situation of shouting during the day and night occurs.